- May 11, 2018
- Posted by: PharmaScroll
- Category:
A study led by the University of Birmingham has found that analysis of fluid in the spine could be used to predict the future progression of multiple sclerosis.
As per a new study by University of Birmingham, a team of scientists investigated whether fluid in the spine could hold the answer to help predict the progression of disability in patients with MS. The findings of the six-year study were published in the Journal of Neurology, Neurosurgery & Psychiatry.
The study saw the team analyse the spinal fluid from patients with MS at the time they were diagnosed and matched these data with the progression of their disease five years later.
The researchers found a highly unusual pattern in the behaviour of white blood cells responsible for immunity and in the antibodies produced by these cells. They found that the cells were producing a significantly higher ratio of one type of antibody molecule. These antibodies originated from cells within the nervous system of these patients – yet these cells are not normally found in this part of the body.
In the blood of MS patients there is a normal ratio of around 2:1 of each type of antibody, but in the spinal fluid of the study’s MS patients the researchers found ratios of more than 100:1.
Joint lead author Dr John Curnow, of the University of Birmingham, added: “What was interesting about our findings was that this unusual extreme ratio bias mostly occurred in patients in the early stages of the disease, while there was far less bias in those patients who later developed greater disability. Our research suggests that this early bias in this type of antibody could be related to a trigger of MS. For patients who later develop more severe disease we find that this attack by the immune system, even when analysed at the time of diagnosis, has already developed beyond the initial trigger of the disease, resulting in greater damage to the nervous system in subsequent years. The unusual pattern of antibody suggests a very distinct immune response early in the disease. We are hoping to identify the target of this immune response. Alongside improving our fundamental understanding of MS, this presents the opportunity to identify patients who are at higher risk of developing disability and may need more aggressive treatment. Similarly, it may be possible to identify patients at lower risk, who may be able to manage their condition more conservatively.”
Dr Curnow said that more research was necessary to validate these research findings, including a study using a larger number of patients. He added: “If our findings are confirmed, then we would have a relatively simple test that could be used at diagnosis to help identify patients with a poor prognosis.This will enable clinicians to justify the use of highly effective therapies, which could potentially improve the long-term outcomes for these patients.”
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News Source: University of Birmingham
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