Migraine associated with Increased Heart stroke risk, says recent analysis

In a recent meta-analysis conducted to evaluate the long-term cardiovascular and cerebrovascular outcomes among migraineurs, it has been established that Migraine headache was associated with an increased long-term risk of cardiovascular and cerebrovascular events.

Construct of the analysis:

The meta-analysis of cohort studies was performed according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines and The MEDLINE, Web of Science and Cochrane Central Register of Controlled Trials databases were searched for relevant articles for the analysis. A total of 16 cohort studies (18 study records) with 394 942 migraineurs and 757 465 non-migraineurs were analysed for outcomes related to major adverse cardiovascular and cerebrovascular events (MACCE), stroke (ie, ischaemic, haemorrhagic or non-specified), myocardial infarction (MI) and all-cause mortality.

Results of the analysis:

Migraine was associated with a higher risk of MACCE (adjusted HR 1.42, 95% confidence interval [CI] 1.26 to 1.60, P<0.001, I2=40%) driven by a higher risk of stroke (adjusted HR 1.41, 95% CI 1.25 to 1.61, P<0.001, I2=72%) and MI (adjusted HR 1.23, 95% CI 1.03 to 1.43, P=0.006, I2=59%). There was no difference in the risk of all-cause mortality (adjusted HR 0.93, 95% CI 0.78 to 1.10, P=0.38, I2=91%), with a considerable degree of statistical heterogeneity between the studies. The presence of aura was an effect modifier for stroke (adjusted HR aura 1.56, 95% CI 1.30 to 1.87 vs adjusted HR no aura 1.11, 95% CI 0.94 to 1.31, P interaction=0.01) and all-cause mortality (adjusted HR aura 1.20, 95% CI 1.12 to 1.30 vs adjusted HR no aura 0.96, 95% CI 0.86 to 1.07, Pinteraction<0.001).

Based on the results, it was concluded that Migraine headache was associated with an increased long-term risk of cardiovascular and cerebrovascular events. This effect was due to an increased risk of stroke (both ischaemic and haemorrhagic) and MI. There was a moderate to severe degree of heterogeneity for the outcomes, which was partly explained by the presence of aura.

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News Source: https://www.ncbi.nlm.nih.gov/pubmed/29593023

Image Source: http://www.mymedicalmantra.com/migraine-interlinked-with-increased-risk-of-developing-heart-disease/