Phase 1 trial announced for a potential MS drug RTA 1701

Reata Pharmaceuticals announced the initiation of a Phase 1 clinical trial of Reata’s RTA 1701, a highly selective and orally bioavailable allosteric RORγt inhibitor.  This Phase 1, first-in-human study is evaluating the safety and pharmacokinetics of RTA 1701 in healthy volunteers and assessing ex vivo suppression of IL-17A secretion.  Initial results are expected in the first half of 2019.

In preclinical studies, RTA 1701 exhibited potent inhibition of the expression of IL-17A, a key cytokine involved in the development and progression of autoimmune diseases.  In a two-week study in non-human primates, RTA 1701 produced significant suppression of ex vivo stimulation of IL-17A secretion in whole blood in both a dose- and concentration-dependent manner, with significant effects observed as early as 24 hours after the first administration.  In this non-human primate study, RTA 1701 also demonstrated dose-dependent systemic exposure over a broad dose range and a pharmacokinetic profile that supports once-daily oral administration.  Other in vitro studies demonstrated that expression of IL-17A was significantly reduced by RTA 1701 treatment in blood samples from patients with rheumatoid arthritis and psoriasis.  Additionally, RTA 1701 has demonstrated significant efficacy after oral dosing in rodent models of rheumatoid arthritis and multiple sclerosis. RTA 1701 was discovered by Reata, who holds global rights for the asset.

“We are excited to have clinical development underway with RTA 1701,” said Keith Ward, Ph.D., Reata’s Chief Development Officer.  “RTA 1701 offers a unique, differentiated profile compared to other agents in this space owing to its novel allosteric binding mode, and we believe that it offers the potential to be a best-in-class oral inhibitor of RORγt for the treatment of patients with autoimmune and inflammatory disorders.”

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News Source: Reata Pharmaceuticals Website

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